Individual risk and population harm associated with smoking cigarettes potentially may be reduced by offering reduced-risk alternative products to smokers who are not willing to quit. Product acceptance is an important factor for risk reduction 1. Therefore, Philip Morris International (PMI) is developing a portfolio of potential Modified Risk Tobacco Products (MRTPs), also referred to as Reduced Risk Products (RRPs) , to address a wide range of adult smoker preferences. These products aim at preserving as much as possible the taste, sensory experience, nicotine delivery profile and ritual characteristics of cigarettes while reducing or eliminating the formation of harmful and potentially harmful constituents (HPHCs) in the inhaled aerosol.

The quality of the scientific substantiation of MRTPs' associated risk is of the foremost importance. INTERVALS will allow all relevant stakeholders to share the data they have produced in relation to the toxicity assessment of MRTPs and alternative products as well as the interpretation of the results they have obtained.

In the first release of INTERVALS, Philip Morris International R&D (for more details, please refer to pmiscience.com) shares results obtained during the assessment of a heat-not-burn platform in in vivo and in vitro studies.

The goal is to grow this initiative and to establish a public repository for 21st century preclinical systems toxicology MRTP assessment data and results, supporting open data principles.

Link to Background page
Link to Data search page
Link to Mechanisms page
Link to Studies page
Link to Tools page
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⚑ Reduced-Risk Products (“RRPs”) is the term we use to refer to products that present, are likely to present, or have the potential to present less risk of harm to smokers who switch to these products versus continued smoking. We have a range of RRPs in various stages of development, scientific assessment and commercialization. Because our RRPs do not burn tobacco, they produce far lower quantities of harmful and potentially harmful compounds than found in cigarette smoke.